Das Synatech - Institut für Synergetik und nachhaltige Technologien

Ein Institut der Arnold-Sommerfeld-Gesellschaft e.V. (ASG)
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21. Oculomotor Meeting
4.-5. February 2011

Poster 15

Neuropathological correlates of oculomotor deficits in progressive supranuclear palsy (PSP)

Anja K.E. Horn, Sigrun Roeber, Vera Ogunlade, Ahmed Messoudi, Christine Glombik,
Hans A. Kretzschmar

IFBLMU - Integriertes Forschungs- und Behandlungszentrum für Schwindel, Gleichgewichts- und Okulomotorikstörungen, Institute of Neuropathology and Institute of Anatomy, LMU München

Progressive supranuclear palsy (PSP) is a clinically and neuropathologically heterogeneous disorder with neuronal and glial tau-immunoreactive inclusions in different brain regions. Vertical gaze palsy is the hallmark of clinical symptoms present within the first two years. In a first attempt to correlate vertical gaze impairment with degenerative changes of premotor saccadic neurons and to establish a working protocol, we performed a post-mortem analysis of a PSP-case with slowed vertical saccades. Sections containing the oculomotor nucleus, interstitial nucleus of Cajal (INC), rostral interstitial nucleus of the medial longitudinal fascicle (RIMLF) and omnipause neurons (OPN) were immunostained for pathologic tau-protein. Premotor burst neurons and OPNs were identified by immunostaining for parvalbumin or non-phosphorylated neurofilaments. A mild to moderate number of tau-positive OPNs and premotor neurons in INC and RIMLF was found. Thereby for the first time an analysis of degenerative changes of identified functional neurons of the saccadic system in PSP is presented.

Supported by the BMBF (IFB -01EO0901)

© 2015  Dr. Uwe Renner